FluidFM® AFM Series
POWERFUL UPGRADE SOLUTIONS FOR AFM SYSTEMS.
The FluidFM ADD-ON greatly extends the application scope of classical atomic force microscopes (AFMs) beyond imaging and force spectroscopy. Take advantage of more than 8 distinctive applications, now accessible thanks to the FluidFM ADD-ON.
The FluidFM ADD-ON is tailored to specific AFM scan heads and brings you the highest flexibility by enabling all FluidFM applications – from single cell adhesion, through nano-injection into single cells and colloidal studies, to nano-printing and beyond.
FluidFM ADD-ON APPLICATIONS GALLERY.
Lucifer yellow injected into HeLa cells with a FluidFM nanosyringe. The injected volumes can be quantified through image analysis and are typically in the range of 50 fL to 300 fL.
A yeast S. Cerevisiae is picked up with a FluidFM micropipette and released again. The adhesion forces and mechanical properties of more than 200 yeasts can be quantified per day in this manner with the FluidFM ADD-ON.
Nano-printing of 2D structures is possible with a FluidFM nanopipette in air or water, and for a wide range of inks and viscosities.
A HeLa cell detached from adherent culture with a FluidFM micropipette. The spherical shape of the cell indicates that it is fully detached. The adhesion force is quantified during the process.
The bacterium S.Pyogenes picked up with a FluidFM nanopipette.
Courtesy E. Potthoff, ETH Zurich
Colloids of 60 µm are picked with a FluidFM micropipette and brought in contact with cell culture to study mechanochemical interactions.
Colloids from sub-µm to 100 µm can be manipulated this way and later released with a pressure pulse.
How the FluidFM ADD-ON brings even more "Bio" into BioAFMs.
SUPPORTED AFM SYSTEMS.
The FluidFM ADD-ON solutions have been developed in cooperation with our AFM partner companies. This allowed to carefully consider the geometrical and physical needs of both the FluidFM parts as well as the AFM system.
Bruker BioScope Resolve
JPK NanoWizard, CellHesion, ForceRobot
Nanosurf FlexAFM and CoreAFM
FluidFM ADD-ON SYSTEM PARTS.
FluidFM probes enabling all FluidFM applications. FluidFM probes are tailored to the geometrical and physical requirements of the specific AFM.
Custom FluidFM probe holder for a specific AFM assuring safe, tight and reliable mounting of FluidFM probes.
FluidFM microfluidics control system (MFCS) to aspirate or release liquids through the FluidFM probe.
Barcode reader to access all relevant probe characteristics, most importantly a unique SEM image of every probe.
A dedicated FluidFM fluorescence camera with a digital filling assistant.
FluidFM CORA software, which gives convenient access and control to all components mentioned above.
The installation is quick and easy: Set the FluidFM ADD-ON up in 20 minutes with the help of this online video.
FluidFM allows my team to efficiently capture adhesive forces of microbial pathogens and screen for new anti-adhesion molecules. I believe that FluidFM has the potential to shed much light onto anti-microbial strategies.
It is a great pleasure to see how much momentum the FluidFM has gained in the scientific community. It astounds me how many different FluidFM applications have been already demonstrated, and still think there is much more to explore both technologically (probes, electrical signals, combination with other instruments) and scientifically (biophysical questions), which is where we are focusing our efforts at ETH.
FluidFM has provided us the chance to detach mammalian cells that were very strongly adhered to the substrate, in a systematic way and without any chemical modification of the cantilever; thus, allowing us to study cell behaviour in their natural state and environment.
EMPOWER YOUR RESEARCH WITH FluidFM.