WORKING WITH THE WORLD'S SMALLEST NANOSYRINGE.

NANO-INJECTION INTO SINGLE CELLS.

FluidFM NANO-INJECTION INTO SINGLE CELLS.

With the FluidFM nanosyringe, the world’s smallest syringe, single cell nano-injection is easy. Change a single cell within a culture and study the cascade effect on its surroundings.

Single cell nano-injection enables targeted introduction of foreign materials into a specific cell. Stimulating selected cells within a colony with your desired drugs or gene vectors provides new insights for life science, biology and medicine.

Choose FluidFM nano-injection as a strong addition to your experimental portfolio.

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FluidFM Single Cell Injection Cell Membrane Penetration

PRECISE

IN CYTOPLASM OR NUCLEUS

FAST

100+ CELLS / HOUR

GENTLE

95%+ CELL VIABILITY

MEASURABLE

FEMTOLITER INJECTED VOLUMES

FAST AND RELIABLE.

During an injection with FluidFM, the inherent force feedback protects both the cell and the FluidFM probe. Thus, ~95% of the injected cells survive the operation unharmed.

A single probe can inject hundreds of cells per hour in an automated process. Simply click on a cell and watch the injection under the microscope. This provides high throughput and makes FluidFM nano-injection both easy and repeatable.

SIMPLIFIED WORKING METHODS.

Highly automated workflows and our intuitive monitoring software support users in every step of their experiment.

The user selects a cell by simply clicking it, based on fluorescent, morphological, or mechanical markers. While monitoring the force, the FluidFM probe approaches the cell and penetrates its membrane. The substance of choice is then injected via a short pressure pulse, and the FluidFM probe retracts again.

Single Cell Injection : Cardiomyocyte injected via FluidFM

Discover FluidFM single cell nano-injection.

Get in touch with us to find out more about single cell nano-injection.

BOT

Conduct your single cell nano-injection experiments with the FluidFM BOT

PROBES

Learn more about the probes which are used for your nano-injection experiments

FACTSHEET

Download our factsheet about single
cell nano-injection

SELECTED PUBLICATIONS

2013

O. Guillaume - Gentil, E. Potthoff, D. Ossola, P. Dörig, T. Zambelli & J. A. Vorholt.
Force-controlled fluidic injection into single cell nuclei.
Small, 9 (11), 1904 – 1907 . doi:10.1002/smll.201202276

2009

Meister, M. Gabi, P. Behr, P. Studer, J. Vörös, P. Niedermann, J. Bitterli, J. Polesel-Maris, M. Liley, H. Heinzelmann & T. Zambelli.
FluidFM: Combining atomic force microscopy and nanofluidics in a universal liquid delivery system for single cell applications and beyond.
Nano Letters, 9 (6), 2501 – 2507. doi:10.1021/nl901384x