FluidFM® CellEDIT Service
A CRISPR cell line engineering service based on our FluidFM® technology.
Sensitive cells? Need a high-quality genome edit?
We create the cell line for you!
Based on our FluidFM technology we have established a CRISPR cell line engineering service that is especially suited for hard-to-transfect and rare cells. We do not shy away from editing primary cells, iPSCs, TERT-immortalized cell lines or other sensitive cell lines – adherent or in suspension. As we work vector-free, we also offer complex edits, like knock-in (KI) with large repair templates or multiple knock-outs (like triple KO). Benefit from novel disease models and complex edits thanks to FluidFM-based CellEDIT Service.
Hard-to-transfect or rare mammalian cells
TERT immortalized cells
Primary cells
iPSCs
Complex edits
Knock-in
Multiple knock-out
Large repair templates
High quality & efficiency
Higher HDR efficiency
Less off-target effects
Guaranteed monoclonality
Example customer projects
| What was done | Cell type | Achievement | |
| Epithelial disease model | CRISPR KO | TERT-immortalized epithelial cells | First time ever successful CRISPR edit for this cell line |
| Undisclosed drug target | CRISPR KI | Undisclosed | 5-10x higher HDR efficiency |
| Diabetes model | CRISPR KI | Hard-to-transfect cell line | CRISPR KI of sensitive cell |
| Skin model | CRISPR KO | TERT-immortalized epidermal cells | CRISPR KO of sensitive cell |
| Triple KO of CHO cells | CRISPR 3x KO in one step | CHO cells | 3x CRISPR KO monoclonal cell line within 3 weeks |
Enabled by FluidFM® technology
Our proprietary FluidFM technology brings genome editing reagents directly into the nucleus. Safe, gentle to the cell, and vector-free! The basis of our technology is a force-controlled nanosyringe that allows precise injection of any soluble cargo directly into the cytoplasm or nucleus of any mammalian cell. And since we start with single cells, monoclonality of cell lines is guaranteed.
