FluidFM ®  systems

Gentle and accurate single-cell injection and cytoplasmic biopsies.

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Overview of FluidFM® systems

FluidFM OMNIUM & ADD-ON

Depending on your specific application and automation needs, and whether you already have a compatible AFM, you may choose the FluidFM ADD-ON or FluidFM OMNIUM Platform.

Features & Benefits

Both FluidFM systems are compatible with the full FluidFM Probe range and can perform all three FluidFM modes - Pick & Place, Injection & Sampling and Dispensing & Nanoprinting. Both systems combine three key features: 

Accurate

The semi-automated workflows and the volume quantification ensure a precise control over your injection or extraction.

Gentle

Whether you want to inject into or extract from the nucleus or the cytoplasm of a single cell, the FluidFM Systems ensure the cell viability.


Versatile

Pick and Place, probe for adhesion, Injection into or extract from a cell in its native environment.

FluidFM ADD-ON​

Powerful and affordable add-on for AFM systems.

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FluidFM OMNIUM

Stand-alone and highly automated system.

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Applications

CRISPR Gene Editing

Find out more about the FluidFM workflow for precision CRISPR genome engineering.

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Single-Cell Profiling

Investigate the potential use of the FluidFM for temporal transcriptome analysis.

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Mechanobiology

Perform cell adhesion measurement with the FluidFM technology.

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FluidFM Systems adapted to your application needs

Explore Applications

System comparison & suitability for each application


 		FluidFM ADD-ON FluidFM OMNI­UM (formerly: FluidFM BOT)
Pre-existing require­ments Needs a compat­ible AFM from third party supplier
 No require­ments
Hard­ware FluidFM module as add-on to existing AFM systems
 Stand­alone FluidFM system with inte­grated micro­scope and force-control unit
Software Exten­sion to software of AFM supplier
 Stand­alone software with dedi­cated work­flows and automa­tion
Automation Limited and depending on AFM system
 Automated workflows available as well as full manual control if needed
Compat­ible probes Full range of FluidFM Nano­syringes, Nano­pipettes, and Micro­pipettes
 Full range of FluidFM Nano­syringes, Nano­pipettes, and Micro­pipettes
Probe replace­ment Easy click-fix mount of probe pre-assem­bled on adaptor, no tools needed
 Automated probe exchange process
Incuba­tor for CO2 and temper­ature control Available (from AFM supplier)
 Available, specially tailored to the FluidFM OMNIUM
Compat­ibility Nanosurf (CoreAFM, FlexAFM and DriveAFM), Bruker (Bio­scope Resolve), JPK (Nano­wizard, CellHesion and ForceRobot families)
 n.a. (stand­alone system)
More informa­tion FluidFM ADD-ON system page
FluidFM OMNI­UM system page

We recommend to conduct all CRISPR cell line development experiments with the FluidFM OMNIUM.
Learn more about the FluidFM OMNIUM system.
Visit the application page and learn more on CRISPR cell line development with FluidFM.


 FluidFM ADD-ON FluidFM OMNI­UM (formerly: FluidFM BOT)
Adhesion measure­ments of mam­malian cells
++ +++
Elasticity or indenta­tion measure­ments of mam­malian cells
+++ ++
Adhe­sion measure­ments of larger microbes like yeast, proto­zoa, or algae
+++ ++
Adhe­sion measure­ments of bacteria
+++ -
Colloidal spec­troscopy
+++ ++
More informa­tion FluidFM ADD-ON system page
FluidFM OMNI­UM system page

- Not recommended; + Works but with drawbacks; ++ Works but not optimal in every situation; +++ Method of choice


Visit the application page and learn more on mechanobiology with FluidFM.


FluidFM ADD-ON FluidFM OMNI­UM (formerly: FluidFM BOT)
Neuronal cell pat­terning
- +++
Injection / appli­cation of drugs (stimula­tion)
+ +++
Trans­fection/ genome editing of neurons
+ +++
Analysis/ omics of single neurons
+ +
Electro­stimula­tion
+ (when com­bined with elec­trode) -
Co-cultiva­tion with other cell types
- +++
More informa­tion FluidFM ADD-ON system page
FluidFM OMNI­UM system page

- Not recommended; + Works but with drawbacks; ++ Works but not optimal in every situation; +++ Method of choice


Visit the application page and learn more on neuroscience with FluidFM.


FluidFM ADD-ON FluidFM OMNI­UM (formerly: FluidFM BOT)
Injection / applica­tion of virions
+ +++
Transfec­tion / genome editing of cells for virus research
+ +++
Cell isolation (Pick & Place)
- +++
Co-cultiva­tion with other cell types / cell pattern­ing
- +++
Analysis / omics of single cells
+ +
More informa­tion FluidFM ADD-ON system page
FluidFM OMNI­UM system page

- Not recommended; + Works but with drawbacks; ++ Works but not optimal in every situation; +++ Method of choice


Visit the application page and learn more on virology with FluidFM.


FluidFM ADD-ON FluidFM OMNI­UM (formerly: FluidFM BOT)
Printing of nano­struc­tures
+++ ++
Printing/ Spotting of arrays
+++ +++
Printing in situ
++ +++
Printing/ Spotting large patterns
- +++
Printing/ Spotting precious samples
+++ +++
More informa­tion FluidFM ADD-ON system page
FluidFM OMNI­UM system page

- Not recommended; + Works but with drawbacks; ++ Works but not optimal in every situation; +++ Method of choice


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Knowledge Center

All FluidFM publications

Coming soon... more researchers' stories with the FluidFM!