Go beyond in single cell manipulation
Gentle and accurate single-cell injection and cytoplasmic biopsies collection
Explore the remarkable capability to manipulate individual cells with the help of the FluidFM technology, including the FluidFM OMNIUM instrument and the CellEDIT service. This cutting-edge technology enables precise injections and extractions across a broad range of cell types and applications while ensuring that cell viability is maintained.
Temporal Single-Cell Profiling
Explore the potential use of the FluidFM for temporal transcriptomics.
CRISPR Gene Engineering
Find out more about the FluidFM workflow for precision gene editing.
Measure cell adhesion with the FluidFM technology in native environment.
Two ways to work with us
The FluidFM technology supports a variety of solutions to cover all dimensions of single-cell manipulation from single-cell handling to the precision genome engineering for custom cell line development.
Monoclonal Cell Line
Hard-to-transfect mammalian cells
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Explore 100+ publications in which FluidFM technology plays a major role. 8+ Ø impact factor.
Interesting insights on the company, applications, or persons working with FluidFM technology.
When we first used FluidFM for extraction, we knew extracting a biopsy from a single cell and transferring it to a substrate for analysis – all whilst keeping the cell alive – is ground-breaking, but we still had many questions to address. The most pressing question was whether the analysed cells are affected at the transcriptome level. What we observed was fascinating – the cell is incredibly resilient; you can press, stretch, and even go into the cell to take out half of the content and the cell does not even have a transcriptional response. This is truly amazing.
It is a great pleasure to see how much momentum the FluidFM has gained in the scientific community. It astounds me how many different FluidFM applications have been already demonstrated, and still think there is much more to explore both technologically (probes, electrical signals, combination with other instruments) and scientifically (biophysical questions), which is where we are focusing our efforts at ETH.
FluidFM is a highly versatile tool with huge potential in the field of single-cell studies. The instrument enables us to address several unanswered questions in the epigenetics field by pushing experimental boundaries.
FluidFM has provided us the chance to detach mammalian cells that were very strongly adhered to the substrate, in a systematic way and without any chemical modification of the cantilever; thus, allowing us to study cell behaviour in their natural state and environment.
FluidFM allows my team to efficiently capture adhesive forces of microbial pathogens and screen for new anti-adhesion molecules. I believe that FluidFM has the potential to shed much light onto anti-microbial strategies.
Cytosurge is a synthetic biology enabler. We are dedicated to fulfilling the unmet need for implementing complex genetic designs into gene-edited mammalian cell lines. We thereby bridge the manufacturing gap between the advances made in data driven genetic design tools and tangible applications of genetically engineered cells.
The company applies a patented single cell bottom-up gene editing process and groundbreaking dynamic gene expression analysis capabilities to construct, evaluate, and debug complex synthetic mammalian cell lines. We are thereby effectively addressing a major pain point of current genetic engineering workflows in mammalian cell lines.
Our initial focus lies in enhancing therapy manufacturing for future cures, with the ultimate goal to empower genetic engineers to concentrate on designing next-generation gene edited mammalian cell lines, confident that their visionary concepts can be realized.