Gentle CRISPR injection into hard-to-transfect cells

Suitable for any cell type maintaining high viability

By delivering CRISPR complexes directly into the nucleus of a specific cell, FluidFM offers a unique in-vitro solution to improve the efficiency and applicability of CRISPR across many hard-to-transfect cell types.

Direct intra-nuclear injection of CRISPR complexes into a neuron with FluidFM

Gentle & direct delivery

Gentle delivery of your CRISPR RNP complexes directly into the nucleus of the target cell.

Simple experimental design

No harsh transfection methods or complex vector design are required when using FluidFM injection.

High cell viability

The specific probe design and automated laser force-feedback control maintain high cell viability across hard-to-transfect cell types.

Injected neuron. Courtesy Sen Yan, Jinan University.

Neuron expressing GFP 24 h after injection of a plasmid encoding GFP using FluidFM. Courtesy of Sen Yan, Jinan University, Guangzhou, China.

Measurement of injected volumes

Measured volumes of fluorescent CRISPR-Cas9 complexes after injection into mouse primary hepatocytes.

Human dermal fibroblast expressing GFP, 24h after injection with FluidFM

Human Dermal Fibroblast injected with GFP mRNA. 70% of injected cells expressed GFP 24h after injection.