Traditional high-dimensional molecular profiling in biology hits the same wall: to measure a cell, you have to kill it, so you never see what it would have become. In genome engineering, conventional delivery methods perturb the cell beyond the intended genetic edit, affecting viability, fitness, or cellular state.

FluidFM addresses both challenges by touching a single living cell with nanoscale precision, keeping it alive whether we are reading its biology or rewriting its genome.

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Applied to single-cell analysis, this enables Live-seq. We read a cell’s molecular state, apply a perturbation, and read the exact same living cell again. Direct cause and effect, not inferred correlation.

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Applied to engineering, the same precision powers CellEDIT’s Impossible Genetic Edits. We deliver CRISPR directly into the nucleus of individual cells with maximum control while preserving the cell’s native state, enabling access to hard-to-transfect cells and large knock-ins beyond the reach of conventional methods.

Together, they create Cytosurge's Same-Cell Biology paradigm: engineering or perturbing a specific living cell, measuring the resulting molecular response, and tracking subsequent phenotypic changes over time, all in the same living cell.