Applications
FluidFM - Go beyond current technological boundaries.
FluidFM BOT BIO Series
Cutting-edge systems for single cell research – from single cell gene editing to drug research and toxicology.
Single cell CRISPR delivery
Direct intra-nuclear CRISPR delivery and bottom-up cell line development.
Single cell drug assays
Deliver compounds directly into the cell. A suitable delivery method for any compound. More>
Cell isolation
Choose the cell you want – place it where you want. No unnecessary cell stress: directly from the culture plate. No extra labelling nor toxic compounds, high viability (> 95%).
Single cell force spectroscopy
Perform single cell force spectroscopy with 10 times higher throughput and much easier cell manipulation and instrument usage. Get sound statistics within a day. More>
Virus research
FluidFM technology can help answer fundamental questions on virus virulence, replication, host immune response and can boost development of novel drugs and vaccines via precise bottom-up approaches.
Nanoprinting
From µm to cm - print any pattern with sub-micrometer resolution in liquid and in air. Any liquid with viscosities ranging from 1 cP to 10'000 cP can be used for printing.
Full versatility for core labs
Unlock original research at the nano- and micro-scale. From gene engineering and cell isolation to single cell adhesion assays, through to micro-patterning of surfaces and the building of neuronal networks. Boost collaboration. For service-based core facilities.
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FluidFM AFM Series
Powerful upgrade solutions for atomic force microscopy (AFM) systems. Take advantage of more than 8 distinctive applications, beyond imaging and force spectroscopy.
Single cell force spectroscopy
FluidFM-based single cell force spectroscopy offers 10 times higher throughput and much easier manipulation of the cells of interest. More>
Single microbe force spectroscopy
For algae, bacteria, fungi, protozoa.
FluidFM increases measurement throughput 10-fold. The versatile method allows to study 20-200 individual microbes a day. More>
Exchangeable colloidal probe
Pick. Measure. Release. Repeat.
With FluidFM, colloidal probe measurements become orders of magnitude easier and faster. More>
Virus research
FluidFM technology can help answer fundamental questions on virus virulence, replication, host immune response and can boost development of novel drugs and vaccines via precise bottom-up approaches.
Selected FluidFM publications
Optimizing drugs
Millions of people suffer from Leukemia around the world. While treatment drugs exist, cancer regularly develops a resistance against them. Researchers from both the University Hospital Würzburg and the University Würzburg found potentially a new approach to overcome resistance to the recently approved Midostaurin drug and even increase the drug's activity, with help of FluidFM cell measurements.
FluidFM: Combining AFM and Nanofluidics
We describe the FluidFM, an atomic force microscope (AFM) based on hollow cantilevers for local liquid dispensing and stimulation of single living cells under physiological conditions. The universality and versatility of the fluidFM will stimulate original experiments at the submicrometer scale not only in biology but also in physics, chemistry, and material science.
Calibrating high-throughput devices
Single cell force spectroscopy offers fundamental insights into many fields yet suffers from low throughput. MTA Budapest tremendously speeds up the acquisition of single cell adhesion data by using FluidFM adhesion measurements to calibrate an optical sensor array. Thus, they are able mechanically monitor more than 1000 adherent cells in parallel.
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