FluidFM® technology


Patented, hollow force sensitive probe technology

FluidFM technology unites the best features of microfluidics and force microscopy.  

Our proprietary FluidFM (Fluidic Force Microscopy) technology uses closed microscopic channels in force sensitive probes. These probes have apertures down to 300 nm and allow to simultaneously sense interaction forces down to pN and to dispense or aspirate femtoliter volumes.  This truly unique combination enables novel experimental designs for a wide range of applications in life sciences, biophysics and mechanobiology.

Check the first publication on FluidFM

Cross section of a FluidFM probe

Microfluidic channel

Enables the handling of femtoliter volumes. Soluble molecules can be dispensed or aspirated through a sub-micrometer aperture at the tip of the probe.

FluidFM nano-injection – the red laser provides the force-feedback

Sensitive force-feedback

Provides a reliable distinction between gentle contact with cell membranes and perforation. Surfaces in liquid environments can be modified in a controlled fashion.

Femtoliter

Control fL liquid volumes

Precise pressure control

With 0.1 mBar resolution

Any viscosity

From 1 to 10'000 cP

FluidFM modes – for a variety of applications

Our hollow FluidFM probes exist in a variety of tip shapes, aperture sizes and mechanical specifications, specifically designed to enable three basic modes. With those three modes and the combinations thereof, innovative new applications in neuroscience, virology, mechanobiology or cell line development become possible.

FluidFM Pick & place

Pick & Place

Grab and relocate single cells and other micro-sized objects.

FluidFM Injection & sampling

Injection & Sampling

Inject into and extract from single cells. Volume quantification possible.

FluidFM Localized dispensing

Localized Dispensing

Grab and relocate single cells and other micro-sized objects.

FluidFM is the ideal solution for cell line development, neuroscience, mechanobiology, and more.

FluidFM probes – different types optimized for your needs

  You didn't find the probe you need? Make your own specific aperture using focused ion beam. Contact us

Convenient & high quality probes

Ready to use

The FluidFM chip, integrating the microfluidics and the hollow cantilever with its specific tip and aperture, comes pre-glued on a convenient adapter tailored to your system. Therefore, FluidFM probes are ready to be filled and used for your experiment.

FluidFM probe zoom in

FluidFM probe zoom in: Every FluidFM probe consists of a polymer adapter, tailored to the specific system, and a FluidFM chip that integrates the microfluidics as well as the hollow cantilever with a specific tip and aperture (last image).

 
 

Get started within minutes

Pipette the desired solution into the reservoir of the probe, connect the probe to your system, fill the microchannel by applying a small positive pressure and the system is ready to be used. 

High quality microfabrication

Our unique, patented microfabrication method ensures reliable and consistent probe quality down to the nanometer scale. We take pride in our Swiss precision and craftsmanship. 

High quality microfabrication
 
 

Know how your probe looks like

FluidFM probes are pre-assembled and individually wrapped in a tailor-made hermetically sealed blister package. The QR-code printed on the package gives convenient access to all relevant probe characteristics, most importantly to a unique SEM image of each individual FluidFM probe taken during our quality control process. You can see exactly how your probe opening looks like. 

Empower your research with FluidFM

References

FluidFM has been invented more than 10 years ago with the first publication appearing in the journal Nanoletters in 2009. Now, we have more than 100 FluidFM installations spread across the globe and count some of the most prestigious corporations and academic institutions to our loyal and very active customer base. In addition, more than 80 high impact publications have been published over the last few years with FluidFM.


100+ Installations

With more than hundred installed FluidFM systems, scientific labs all around the globe are working with our cutting-edge technology.

Academy & Industry

Renowned academic institutions as well as cutting-edge research labs of the industry work with our FluidFM systems.

80+ Publications

Since its invention in 2009, FluidFM facilitates cutting-edge research results in life sciences, biophysics and mechanobiology.
Explore the 80+ publications

Cytosurge reference institutions

... and many more.