from nano-injection into adherent cells to material sciences.

SELECTED FluidFM®  PUBLICATIONS

Application tags

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Application Tags:
Nano-injection, Nano-extraction, Cell isolation, Spotting, Nanolithography, Adhesion of single cells, Adhesion of single bacteria, Colloidal spectroscopy, SICM, Patch clamp, Nanobalance, 3D printing, Surface manipulation, Other, REVIEW.


MAIN PUBLICATION / FluidFM Technology Introduction:

A. Meister, M. Gabi, P. Behr, P. Studer, J. Vörös, P. Niedermann, J. Bitterli, J. Polesel-Maris, M. Liley, H. Heinzelmann & T. Zambelli. FluidFM: Combining atomic force microscopy and nanofluidics in a universal liquid delivery system for single cell applications and beyond. (2009) Nano Letters, 9(6), 2501-2507. doi:10.1021/nl901384x
Spotting, Nanolithography, Nano-injection

 

2018

M. Y. Amarouch, J. E. Hilaly & D. Mazouzi. AFM and FluidFM Technologies: Recent Applications in Molecular and Cellular Biology. Scanning, Volume 2018, Article ID 7801274, 10 pages. doi: 10.1155/2018/7801274
REVIEW

W. N. Deng, S. Wang, J. Ventrici de Souza, T. L. Kuhl & G.-Y. Liu. New Algorithm to Enable Construction and Display of 3D Structures from Scanning Probe Microscopy Images Acquired Layer-by-Layer. The Journal of Physical Chemistry A, 122(26), 5756-5763. doi: 10.1021/acs.jpca.8b03417
Nanolithography

L. Dorwling-Carter, M. Aramesh, H. Han, T. Zambelli & D. Momotenko. Combined Ion Conductance and Atomic Force Microscope for Fast Simultaneous Topographical and Surface Charge Imaging. (2018) Analytical Chemistry, Just Accepted Manuscript. doi: 10.1021/acs.analchem.8b02569
SICM

P. Frederix, P. Werten & D. Yablon. FluidFM: Precise fluidic positioning and delivery platform with applications in cell biology and soft matter. (2018) Microscopy and Analysis, John Wiley & Sons Ltd.
REVIEW

H. M. Grandin, O. Guillaume-Gentil, T. Zambelli, M. Mayer, J. Houghtaling, C. G. Palivan, M. Textor, & F. Höök. Bioinspired, nanoscale approaches in contemporary bioanalytics (Review). (2018) Biointerphases 13, 040801. doi: 10.1116/1.5037582
REVIEW

O. Guillaume-Gentil, M. Mittelviefhaus, L. Dorwling-Carter, T. Zambelli & J. A. Vorholt. FluidFM Applications in Single-Cell Biology. In: E. Delamarche, G. V. Kaigala. Open-Space Microfluidics: Concepts, Impementations, Applications (Chapter 15), 2018, Wiley-VCH Verlag GmbH & Co.
REVIEW

S. Mishra, Y. Lee & J. W. Park. Direct quantification of trace amounts of a chronic myeloid leukemia biomarker using locked nucleic acid capture probes. Analytical Chemistry, Just Accepted Manuscript. doi: 10.1021/acs.analchem.8b03350
Spotting

P. Roder & C. Hille. Local tissue manipulation via a force- and pressure-controlled AFM micropipette for analysis of cellular processes. (2018) Scientific Reports 8:5892. doi: 10.1038/s41598-018-24255-9
Spotting

T. Zambelli, M. J. Aebersold, P. Behr, H. Han, L. Hirt, V. Martinez, O. Guillaume-Gentil & J. Vörös. FluidFM: Development of the Instrument as well as Its Applications for 2D and 3D Lithography. In: E. Delamarche, G. V. Kaigala. Open-Space Microfluidics: Concepts, Impementations, Applications (Chapter 14), 2018, Wiley-VCH Verlag GmbH & Co. Factsheet
REVIEW

J. Zhang, V. A. Piunova, Y. Liu, A. Tek, Q. Yang, J. Frommer , G.-Y. Liu, & J. Sly. Controlled Molecular Assembly via Dynamic Confinement of Solvent. (2018) The Journal Of Physical Chemistry Letters, 9, 6232 - 6237. doi: 10.1021/acs.jpclett.8b02442
Nanolithography, Spotting


2017

M. J. Aebersold, H. Dermutz, L. Demkó, J. F. Saenz Cogollo, S.-C. Lin, C. Burchert, M. Schneider, D. Ling, C. Forró, H. Han, T. Zambelli &J.  Vörös. Local Chemical Stimulation of Neurons with the Fluidic Force Microscope (FluidFM). (Nov 2017) ChemPhysChem, 1439-7641. doi: 10.1002/cphc.201700780
Spotting

N. Cohen, S. Sarkar, E. Hondroulis, P. Sabhachandani & T. Konry. Quantification of intercellular adhesion forces measured by fluid force microscopy. (Nov 2017) Talanta, 174(1), 409-413. doi: 10.1016/j.talanta.2017.06.038
Adhesion of single cells

J.V. de Souza, Y. Liu, S. Wang, P. Dörig, T. L. Kuhl, J. Frommer & G.-Y. Liu.  Three-Dimensional Nanoprinting via Direct Delivery.  The Journal Of Physical Chemistry B. doi: 10.1021/acs.jpcb.7b0697
Nanolithography

O. Guillaume-Gentil, T. Rey, P. Kiefer, A.J. Ibáñez, R. Steinhoff, R. Brönnimann, L. Dorwling-Carter, T. Zambelli, R. Zenobi & J.A. Vorholt. Single-Cell Mass Spectrometry of Metabolites Extracted from Live Cells by Fluidic Force Microscopy. (May 2017) Anal Chem., 89(9), 5017-5023. doi:10.1021/acs.analchem.7b00367
Nano-extraction

N. Helfricht, A. Mark, M. Behr, A. Bernet, H.W. Schmidt & G. Papastavrou. Writing with Fluid: Structuring Hydrogels with Micrometer Precision by AFM in Combination with Nanofluidics. (Aug 2017) Small, 13(31). doi:10.1002/smll.201700962 
Nanolithography

N. Helfricht, A. Mark, L. Dorwling-Carter, T. Zambelli and G. Papastavrou. Extending the Limits of Direct Force Measurements: Colloidal Probes from Sub – Micron Particles. Nanoscale. doi: 10.1039/C7NR02226C.
Colloidal spectroscopy

L. Hirt, A. Reiser, R. Spolenak & T. Zambelli. Additive Manufacturing of Metal Structures at the Micrometer Scale. Advanced Materials, 29(17). doi: 10.1002/adma.201604211 REVIEW, 3D printing

S. G. Higgins, M. M. Stevens. Extracting the contents of living cells – Alumnia “nanostraws” enable longitudinal intracellular monitoring of live cells. (April 2017) Science, 356(6336). doi: 10.1126/science.aan2734
REVIEW, Nano-extraction

L. Jaatinen. The Effect of an Applied Electric Current on Cell Proliferation, Viability, Morphology, Adhesion, and Stem Cell Differentiation. Tampere: Tampere University of Technology. Retrieved from https://tutcris.tut.fi/portal/files/10441293/jaatinen_1462.pdf
Adhesion of single cells

A. Sancho, I. Vandersmissen, S. Craps, A. Luttun, & J. Groll. A new strategy to measure intercellular adhesion forces in mature cell-cell contacts. (April 2017) Scientific Reports, 7(46152), doi: 10.1038/srep46152
Adhesion of single cells

S. Sankaran, L. Jaatinen, J. Brinkmann, T. Zambelli, J. Vörös & P. Jonkheijm. Cell Adhesion on Dynamic Supramolecular Surfaces Probed by Fluid Force Microscopy-Based Single-Cell Force Spectroscopy. (Apr 2017) ACS Nano., 11(4), 3867-3874. doi:10.1021/acsnano.7b00161
Adhesion of single cells

K. S. Sprecher, I. Hug, J. Nesper,E. Potthoff, M. A. Mahi, M. Sangermani, V. Kaever, T. Schwede, J. Vorholt, U. Jenal. Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein. mBio (American Society for Miobiology) 8(2). doi: 10.1128/mBio.00294-1
Adhesion of single bacteria


2016

O. Guillaume-Gentil, R.V. Grindberg, R. Kooger, L. Dorwling-Carter, V. Martinez, D. Ossola, M. Pilhofer, T. Zambelli & J.A. Vorholt. Tunable Single-Cell Extraction for Molecular Analyses. (Jul 2016) Cell, 166(2), 506-516. doi: 10.1016/j.cell.2016.06.025.
Nano-extraction

N. Helfricht, E. Doblhofer, J. F.L. Duval, T. Scheibel & G. Papastavrou. Colloidal Properties of Recombinant Spider Silk Protein Particles. Journal of Physical Chemistry C, 120(32), doi:10.1021/acs.jpcc.6b03957
Colloidal spectroscopy

L. Hirt, S. Ihle, Z. Pan, L. Dorwling-Carter, A. Reiser, J.M. Wheeler, R. Spolenak, J. Vörös & T. Zambelli. Template-Free 3D Microprinting of Metals Using a Force-Controlled Nanopipette for Layer-by-Layer Electrodeposition. Advanced materials. doi:10.1002/adma.201504967
3D printing

L. Jaatinen, E. Young, J. Hyttinen, J. Vörös, T. Zambelli & L. Demkó. Quantifying the effect of electric current on cell adhesion studied by single-cell force spectroscopy. Biointerphases, 11(1), 011004. doi:10.1116/1.4940214
Adhesion of single cells

H. Koo, I. Park, Y. Lee, H.J. Kim, J.H. Jung, J.H. Lee, Y. Kim, J.-H. Kim & J.W. Park. Visualization and Quantification of MicroRNA in a Single Cell Using Atomic Force Microscopy. Journal of the American Chemical Society, jacs.6b05048. doi:10.1021/jacs.6b05048
Spotting

Y. Lee, Y. Kim, D. Lee, D. Roy & J.W. Park.Quantification of Fewer Than Ten Copies of a DNA Biomarker without Amplification or Labeling. Journal of the American Chemical Society, jacs.6b02791. doi:10.1021/jacs.6b02791
Spotting

J.S. McGrath, J. Quist, J.R.T. Seddon, S.C.S. Lai, S.G. Lemay & H.L. Bridle. Deformability Assessment of Waterborne Protozoa Using a Microfluidic-Enabled Force Microscopy Probe. PLOS ONE, 11(3), e0150438. doi:10.1371/journal.pone.0150438
Adhesion of single cells, Adhesion of single bacteria

D. Ossola, P. Dörig, J. Vörös, T. Zambelli & M. Vassalli. Serial weighting of micro-objects with resonant microchanneled cantilevers. (Oct 2016) Nanotechnology, 27(41), 415502. doi: 10.1088/0957-4484/27/41/415502
Nanobalance

 

2015

J. Geerlings, E. Sarajlic, E.J.W. Berenschot, R.G.P. Sanders, M.H. Siekman, L. Abelmann & N.R. Tas. Electric field controlled nanoscale contactless deposition using a nanofluidic scanning probe.  Applied Physics Letters, 107(12), 123109. doi:10.1063/1.4931354
Spotting, Nanolithography

R.R. Grüter, B. Dielacher, L. Hirt, J. Vörös & T. Zambelli. Patterning gold nanoparticles in liquid environment with high ionic strength for local fabrication of up to 100 µm long metallic interconnections.  Nanotechnology, 26(17), 175301. doi:10.1088/0957-4484/26/17/175301
Nanolithography

L. Hirt, R.R. Grüter, T. Berthelot, R. Cornut, J. Vörös & T. Zambelli. Local surface modification via confined electrochemical deposition with FluidFM.  RSC Adv., 5(103), 84517 — 84522. doi:10.1039/C5RA07239E
Nanolithography

D. Ossola, M.-Y. Amarouch, P. Behr, J. Vörös, H. Abriel & T. Zambelli. Force-controlled patch clamp of beating cardiac cells. Nano letters, 15(3), 1743 — 50. doi:10.1021/nl504438z
Patch clamp

D. Ossola, L. Dorwling-Carter, H. Dermutz, P. Behr, J. Vörös & T. Zambelli. Simultaneous Scanning Ion Conductance Microscopy and Atomic Force Microscopy with Microchanneled Cantilevers. Physical Review Letters, 115(23), 238103. doi:10.1103/PhysRevLett.115.238103
SICM

E. Potthoff, D. Ossola, T. Zambelli & J.A. Vorholt. Bacterial adhesion force quantification by fluidic force microscopy. Nanoscale, 7(9), 4070 — 4079. doi:10.1039/c4nr06495j
Adhesion of single bacteria

P. Roder & C. Hille. A Multifunctional Frontloading Approach for Repeated Recycling of a Pressure-Controlled AFM Micropipette. PLOS ONE, 10(12), e0144157. doi:10.1371/journal.pone.0144157
Spotting

B.R. Simona, L. Hirt, L. Demkó, T. Zambelli, J. Vörös, M. Ehrbar & V. Milleret. Density gradients at hydrogel interfacesfor enhanced cell penetration. Biomater. Sci. doi:10.1039/C4BM00416G
Colloidal spectroscopy

 

2014

H. Dermutz, R.R. Grüter, A.M. Truong, L. Demkó, J. Vörös & T. Zambelli. Local polymer replacement for neuron patterning and in situ neurite guidance.   Langmuir: the ACS journal of surfaces and colloids, 30(23), 7037 — 46. doi:10.1021/la5012692
Spotting, Nanolithography

J. Geerlings, E. Sarajlic, J.W. Berenschot, R.G.P. Sanders, L. Abelmann & N.R. Tas.  Electrospray deposition from AFM probes with nanoscale apertures.  In MEMS 2014 (pp. 100 — 103). San Francisco: IEEE. Retrived from  http://ieeexplore.iee.org/xpls/abs_all.jsp?arnumber=676558 
Spotting, Nanolithography

O. Guillaume-Gentil, E. Potthoff, D. Ossola, C.M. Franz, T. Zambelli & J.A. Vorholt. Force-controlled manipulation of single cells: From AFM to FluidFM. Trends in Biotechnology. Elsevier Ltd. doi:10.1016/j.tibtech.2014.04.008
REVIEW

O. Guillaume-Gentil, T. Zambelli & J.A. Vorholt. Isolation of single mammalian cells from adherent cultures by fluidic force microscopy. Lab on a chip, 14(2), 402 — 14. doi:10.1039/c3lc51174j
Cell isolation

E. Potthoff, D. Franco, V.D'Alessandro, C. Starck, V. Falk, T. Zambelli, J.A. Vorholt, D. Poulikakos & A. Ferrari. Toward a rational design of surface textures promoting endothelialization. Nano Letters, 14(2), 1069 — 1079. doi:10.1021/nl4047398
Adhesion of single cells

 

2013

P. Dörig, D. Ossola, A.M. Truong, M. Graf, F. Stauffer, J. Vörös & T. Zambelli. Exchangeable colloidal AFM probes for the quantification of irreversible and long-term interactions.   Biophysical Journal, 105(2), 463 — 472. doi:10.1016/j.bpj.2013.06.002
Colloidal spectroscopy

R.R. Grüter, J. Vörös & T. Zambelli. FluidFM as a lithography tool in liquid: spatially controlled deposition of fluorescent nanoparticles.  Nanoscale, 5(3), 1097 — 104. doi:10.1039/c2nr332140k
Nanolithography

O. Guillaume-Gentil, E. Potthoff, D. Ossola, P. Dörig, T. Zambelli & J.A. Vorholt. Force-controlled fluidic injection into single cell nuclei.  Small, 9(11), 1904 — 1907. doi:10.1002/smll.201202276
Nano-injection

P. Schön, J. Geerlings, N. Tas & E. Sarajlic. AFM Cantilever with in Situ Renewable Mercury Microelectrode.  Analytical chemistry, 85(19), 8937 — 42. doi:10.1021/ac400521p
Other

P. Stiefel, T. Zambelli & J.A. Vorholt.  Isolation of optically targeted single bacteria by application of fluidic force microscopy to aerobic anoxygenic phototrophs from the phyllosphere.  Applied and Environmental Microbiology, 79(16), 4895 — 4905. doi:10.1128/AEM.01087-13
Cell isolation


2012

E. Potthoff, O. Guillaume-Gentil, D. Ossola, J. Polesel-Maris, S. LeibundGut-Landmann, T. Zambelli & J.A. Vorholt. Rapid and Serial Quantification of Adhesion Forces of Yeast and Mammalian Cells.  PLOS ONE, 7(12), e52712. doi:10.1371/journal.pone.0052712
Adhesion of single cells

P. Stiefel, F.I. Schmidt, P. Dörig, P. Behr, T. Zambelli, J.A. Vorholt & J. Mercer. Cooperative vaccinia infection demonstrated at the single-cell level using FluidFM.  Nano Letters, 12(8), 4219 — 4227. doi:10.1021/nl3018109
Spotting

 

2010

P. Dörig, P. Stiefel, P. Behr, E. Sarajlic, D. Bijl, M. Gabi, J. Vörös, J.A. Vorholt & T. Zambelli. Force-controlled spatial manipulation of viable mammalian cells and micro-organisms by means of FluidFM technology. Applied Physics Letters, 97(2), 023701 1 — 3. doi:10.1063/1.3462979
Cell isolation

 

2009

A. Meister, J. Polesel - Maris, P. Niedermann, J. Przybylska, P. Studer, M. Gabi, P. Behr, T. Zambelli, M. Liley, J. Vörös & H. Heinzelmann. Nanoscale dispensing in liquid environment of streptavidin on a biotin-functionalized surface using hollow atomic force microscopy probes. (2009) Microelectronic Engineering, 86(4-6), 1481 – 1484. doi:10.1016/j.mee.2008.10.025
Spotting

A. Meister, M. Gabi, P. Behr, P. Studer, J. Vörös, P. Niedermann, J. Bitterli, J. Polesel - Maris, M. Liley, H. Heinzelmann & T. Zambelli. FluidFM: Combining atomic force microscopy and nanofluidics in an universal liquid delivery system for single cell applications and beyond. (2009) Nano Letters, 9 (6), 2501–2507. doi:10.1021/nl901384x
Spotting, Nanolithography, Nano-injection