FluidFM® ADD‑ON for Nanosurf AFMs


To extend the capability of your Nanosurf AFM with FluidFM ADD-ON:

Nanosurf AFM with a FluidFM ADD-ON

Nanosurf logo

Extend the application scope of your Nanosurf atomic force microscope with our FluidFM ADD-ON.  The FluidFM technology brings microfluidics to the tip of an AFM cantilever. The FluidFM ADD-ON is available for the Nanosurf DriveAFM,  FlexAFM and CoreAFM  platforms.

Safe & reliable

The custom FluidFM probe holder for your AFM assures safe, tight and reliable mounting of FluidFM probes without the need of any tweezers.

Close-up of the Nanosurf FlexAFM scan head with a mounted FluidFM probe.
 
 

Easy & fast probe mounting

The mounting of a FluidFM probe onto your AFM is fast and simple and does not require any tooling. The video (courtesy of Nanosurf) shows how a FluidFM probe is filled and mounted onto a Nanosurf FlexAFM.

Tailored to each system

Our FluidFM probe adapters are tailored to the geometrical and physical requirements of your Nanosurf AFM.

FluidFM probe with a Nanosurf adapter

Are you looking for a standalone platform suited for Life Sciences application?

Use Cases with a FluidFM ADD-ON & Nanosurf AFMs

Mechanobiology

Colloidal spectroscopy of HeLa cells

A colloid is picked up by FluidFM and used to probe a living cell and create a force map. The FluidFM microfluidic control is fully integrated into the AFM software.

Image courtesy of Nanosurf AG. Left image: Map of Young's modulus (blue area is on glass). Right image: Approach curves (force in nN versus tip-sample distance in µm) for the locations indicted with a star on the left: on glass (blue), harder cell areas (orange) and softer cell areas (black).

Cell adhesion measurements

 
 

Video courtesy of Nanosurf AG. Cell adhesion measurement at Harvard Center for Nanoscale Systems with a Nanosurf AFM.

Study of tumor progression and metastasis with cell-cell adhesion forces

FluidFM Mechanobiology - Cell-cell adhesion (Data/image courtesy of Tanya Konry group, Northeastern University, Boston, USA)

Data/image courtesy of Tanya Konry group, Northeastern University, Boston, USA.

Study with a Nanosurf Flex-FPM by Dr. Noa Cohen, group of Prof. Tanya Konry, Northeastern University in Boston, on cell-cell adhesion forces to gain more insights into tumor progression and metastasis (Cohen et al., 2017):


Optical images showing:
A) a single cell to be picked up by a FluidFM probe
B) the cell aspired to the cantilever and
C) the FluidFM probe with aspired cell during a cell-cell adhesion measurement. 

FluidFM Mechanobiology - Cell-cell adhesion (Data/image courtesy of Tanya Konry group, Northeastern University, Boston, USA)

Data/image courtesy of Tanya Konry group, Northeastern University, Boston, USA. A) Typical force curves between a MCF7 cell aspired to the cantilever and non-cancerous, fibroblast (HS5) on the substrate at different contact times. B) Development of the force with contact time between the cells.


Nanoprinting

Create grids & patterns

FluidFM Nanoprinting - Spotting (Image courtesy of Nanosurf AG)

Image courtesy of Nanosurf AG.

Deposit (bio)molecules and particles at defined locations with micrometer accuracy and with femtoliter volumes. A wide range of inks can be deposited in both air and liquid environment - from water to honey, solvents, acids, bases and more. For nanoscale and biomedicine research, biosensors and biomaterials. Automatically varying back pressure and contact time in a grid-like pattern (3 dots per condition), spot sizes can be quickly optimized.

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