MEASURING CELLULAR ADHESION AT THE CELL LEVEL.
SINGLE CELL ADHESION
BOOST YOUR RESEARCH PRODUCTIVITY.
Cells bind to various surfaces and substrates. Measuring cellular adhesion at the cell level provides valuable insight for many research topics in biology and medicine.
Until now, measuring these interactions was highly complex and time-consuming. But with FluidFM technology you can boost your research productivity: Gain unprecedented insights into organ formation, implant surface properties and pathogen pathways.
CELLS A DAY
THAN STANDARD METHODS
10x HIGHER FORCE RANGE
THAN STANDARD METHODS
GAIN MORE INSIGHTS. FASTER.
Reduced preparation time in combination with reusable measurement probes makes FluidFM the perfect tool for all your single cell adhesion studies.
Thanks to the unique properties of FluidFM technology you can gather solid cell adhesion data in a short time. Gain access to unparalleled measurement ranges, increasing your experimental flexibility. FluidFM gives you the edge.
Highly automated workflows and our intuitive monitoring software support users in every step of their experiment.
The target cell is selected via the point and click interface and then reversibly attached to the FluidFM probe by applying an under pressure. It is subsequently detached from the surface by retracting the measurement probe, and the resulting adhesion forces are precisely recorded with pN resolution. All force curves are automatically stored and organized for analysis using our advanced data analysis software or custom third-party tools.
N. Cohen, S. Sarkar, E. Hondroulis, P. Sabhachandani & T. Konry.
Quantification of intercellular adhesion forces measured by fluid force microscopy.
(Nov 2017) Talanta, 174(1), 409-413. doi: 10.1016/j.talanta.2017.06.038
L. Jaatinen. The Effect of an Applied Electric Current on Cell Proliferation, Viability, Morphology, Adhesion, and Stem Cell Differentiation. Tampere: Tampere University of Technology. Retrieved from https://tutcris.tut.fi/portal/files/10441293/jaatinen_1462.pdf
A. Sancho, I. Vandersmissen, S. Craps, A. Luttun, & J. Groll. A new strategy to measure intercellular adhesion forces in mature cell-cell contacts. (April 2017) Scientific Reports, 7(46152), doi: 10.1038/srep46152
S. Sankaran, L. Jaatinen, J. Brinkmann, T. Zambelli, J. Vörös & P. Jonkheijm. Cell Adhesion on Dynamic Supramolecular Surfaces Probed by Fluid Force Microscopy-Based Single-Cell Force Spectroscopy.
(Apr 2017) ACS Nano., 11(4), 3867-3874. doi:10.1021/acsnano.7b00161
L. Jaatinen, E. Young, J. Hyttinen, J. Vörös, T. Zambelli & L. Demkó. Quantifying the effect of electric current on cell adhesion studied by single-cell force spectroscopy. Biointerphases, 11(1), 011004. doi:10.1116/1.4940214
J.S. McGrath, J. Quist, J.R.T. Seddon, S.C.S. Lai, S.G. Lemay & H.L. Bridle. Deformability Assessment of Waterborne Protozoa Using a Microfluidic-Enabled Force Microscopy Probe. PLOS ONE, 11(3), e0150438. doi:10.1371/journal.pone.0150438
E. Potthoff, D. Franco, V. D’Alessandro, C. Starck, V. Falk, T. Zambelli, J. A. Vorholt, D. Poulikakos & A. Ferrari. Toward a rational design of surface textures promoting endothelialization. Nano Letters, 14 (2), 1069 – 1079. doi:10.1021/nl4047398
E. Potthoff, O. Guillaume - Gentil, D. Ossola, J. Polesel - Maris, S. LeibundGut - Landmann, T. Zambelli & J. A. Vorholt. Rapid and Serial Quantification of Adhesion Forces of Yeast and Mammalian Cells.
PLoS ONE, 7 (12), e52712. doi:10.1371/journal.pone.0052712