Deliver compounds directly into the cell.

A suitable delivery method for any compound.

 Direct delivery

Bypass membrane impermeability and bring any compound into the intracellular environment.              

 
 

 Easy to use

Intuitive user interface and automated injection process. Keep your focus on the science.

 
 

A nano-syringe for cells

 

 

Through cell- and nuclear- membranes

  • No issues due to compounds selective permeability​

  • No need for vectors / chemical modification to pass through the cellular membrane​

  • Target the nucleus or cytoplasm​

Autonomous delivery

  • Patented autonomous injection method

  • ​Gentle procedure guarantees high cell viability

  • High reproducibility

 

Deliver any substance

  • Choose what you inject​

  • Know how much you injected

  • Only 1 µl of the substance is required to inject 1000's of cells

Easy

  • System ready in 10 minutes

  • Full point&click software support




Fluorescent CRISPR-Cas9 complexes injected into mouse primary hepatocytes with the FluidFM Bio-CRISPR.

Cell viability for injected HeLa and CHO cells. 

> 95% viability

The cellular membrane self-heals upon withdrawal of the FluidFM nanosyringe leading to > 95% viability.

          Simplify & accelerate early drug-development


          Study a drug effect without complications on its delivery.

          - Decouple drug-effects from side-effects caused by the delivery method.
          - Check the effect of your drug before optimizing its delivery.
          - Overcome the problem of drug membrane permeability during early drug development.



          Discuss your experiment with our experts

          Know the injected volume for each single cell



          The amount of injected drug can be measured with femtoliter precision for each single cell, when co-injected with a fluorescent marker. The volume measurement tool guides you step-by-step towards a self-generated report.​


          What is the actual delivered volume? Measuring the injected volume per cell allows to precisely know the real drug uptake, thus accounting for cell heterogeneity.

          Get dose-response curves at single cell level. Infer on drug properties and their effect at a single cell level.

          Fluorescent CRISPR-Cas9 complexes injected into mouse primary hepatocytes with the FluidFM Bio-CRISPR.

          CHO cells injected with Lucifer Yellow.

          Fluorescent CRISPR-Cas9 complexes injected into mouse primary hepatocytes with the FluidFM Bio-CRISPR.

                 Volume quantification for hepatocytes injected with Lucifer Yellow.

          Compatible with virtually any compounds & adherent cell lines

          Fluorescent CRISPR-Cas9 complexes injected into mouse primary hepatocytes with the FluidFM Bio-CRISPR.

          Mouse primary neurons injected with  Lucifer yellow and GFP plasmids. Courtesy of   Jinan University, Guangzhou, China.

          Compounds

          • Nanoparticles

          • Lipids

          • Exogenous proteins

          • Nucleic acids

          • And many more, with viscosities from water to honey 


          Cell lines


          Observe & follow the response

          Targeted cells can be long-term imaged to investigate phenomena such us:

          • Drug clearance
          • Intracellular drug aggregation
          • Drug subcellular localization
          •  Compound toxicity
           
           

          Protein degradation time-lapse over 5 hours after FluidFM nano-injection.

          Webinar with a live demo:

          Direct delivery and precise volume calculation

          • Get to know FluidFM as a tool for single cell research.

          • Understand how FluidFM nano-injection works and how it empowers single cell research.

          • Learn how to measure the volume injected into each single cell and which applications can benefit from it.

           

          Odoo • Text and Image



          Sign up for product news & interesting updates about Cytosurge and FluidFM technology.

          To find out more about how we use your data, read our full privacy policy.


          Subscribe Thanks
          Thanks for your subscription!