FluidFM® BOT BIO Series

EVERY SINGLE CELL COUNTS. SOLUTIONS FOR CELL EDITING, ASSAYS AND CELL LINE DEVELOPMENT STARTING WITH ONLY A FEW DOZENS OF CELLS.

The FluidFM BIO Series offers tailored systems to your problem – from single cell gene editing to drug research and toxicology on a single cell level. Discover how FluidFM can help you in your field:

FOR CUTTING-EDGE RESEARCH

The BIO Series enables unprecedented single cell experiments based on the patented FluidFM technology. Inject into single cells, edit their genome, isolate cells from a culture and much more with these cutting-edge systems:

  • The patented FluidFM technology has already led to more than 60 high-impact publications.

  • Many possible applications:

    • Nano-injection into single cells (of CRISPR, drugs, nanoparticles, ...)

      • Place your cell culture, select the cells of interest. The system autonomously injects into the selected cells. Process hundreds of cells/hour.

      • With a few clicks, quantify the injected volume within the software.

      • Follow each cells’ fate with fully integrated epi-fluorescence microscopy.

      • Study the dose-response statistics for your injected compound.

    • Isolation of single cells (pick & place, cell sorting, ...)

      • Isolate cells of your choice from an adherent, confluent culture to a separate well.

      • Create monoclonal colonies or analyze the selected cells with 3rd party systems of your choice.

    • Nano-printing (of biomolecules, biomaterials, nanoparticles, ...)

      • Print spots, high-density arrays or even complex patterns with nanometer precision, useful for example in biosensing to create protein or DNA arrays.

      • Also Poly-L-Lysine can be nano-printed to create submicron structures which will act as scaffolds for controlled cell growth.

    • Single cell adhesion measurements

  • Unlock the full potential using FluidFM nanosyringes, nanopipettes and micropipettes and combine the different applications for unique, unprecedented experiments. Example: Inject cells of your choice, nano-extract cell content to follow their fate, isolate and expand the most promising candidates.

  • Largely automated

  • Intuitive, simple user interface

  • Learn to use in one day

  • Reliable, safe and fun - just follow the workflows, reduce repetitive tasks, reduce human errors, replicate past experiments

  • Watch live-demos here

  • >95% viability for any single cell manipulation

  • Higher viability than any other single cell technique

  • System with 37°C incubator and optional integrated CO2 control

  • Perform any experiment on adherent cell cultures and keep the valuable context information. A unique advantage of FluidFM technology.

Our software records the XY-coordinates of the edited cells and allows the user long-term observation of the modified cells with the desired settings (fluorescence filter, exposure time etc…) or even further manipulation of the same cells. Observe any point of interest and follow how events unfold with multi-channel time-lapses.

  • 360° support: Experimental design, data interpretation, …

FluidFM BIO Series
 
 

Working principle of the BIO Series products shown with nano-injection into adherent cells.

BUILT FOR CELL BIOLOGY

Incubator

Coming with a fully integrated incubation environment for extended cell studies: 37°C and CO2 control.

Compatible

Fully compatible with standard cell culture containers from petri-dishes to 2x24 well plates.

Bio optics

Automated 3 color epi-fluorescence, with research grade optics.

Built-in cell know-how

Coming with a comprehensive database of protocols and appropriate parameter for all popular cell lines.

Stay in control

Continuous visual feedback on your cells also during the manipulation.